Table 1 Characteristic of included studies
Study | Year | Country | Design | Surgery performed | Study size | Groups | Outcomes | |
|---|---|---|---|---|---|---|---|---|
TXA | Control | |||||||
Dell’Amore A et al | 2012 | Italy | RCT | pulmonary resection | 87 | 5 g TXA; Thoracic topical administration N=44 | Saline N=43 | ①②③④⑤⑦ |
Sabry MM et al | 2018 | Egypt | RCT | decortication surgery for chronic thoracic empyema, encysted effusion, or clotted hemothorax | 70 | 3 g TXA; Thoracic topical administration N=35 | Saline N=35 | ①②③⑤⑦ |
Kuint R et al | 2020 | Israel | RCT | bronchoscopy and TBLB | 50 | 0.5gTXA; instilled in the target lobar bronchus N=26 | Saline N=24, | ⑥⑦ |
Wang LT et al | 2021 | China | RCT | lobectomy | 60 | 2gTXA; Thoracic topical administration N=20 | Saline N=20 | ①②④⑤⑦ |
3gTXA; Thoracic topical administration N=20 | ||||||||
Hu Y et al | 2006 | China | RCT | lobectomy and esophagectomy | 40 | 10mg/ kg as a bolus; 1mg·kg-1·h-1 continuous infusion during the surgery N=20 | Saline N=20 | ②⑥ |