Table 1 Characteristics of TBC in most previous English case reports (excluding the case series of Brown JG et al.)
From: A basaloid carcinoma with multilocular thymic cyst mimicking a mediastinal teratoma
Study | Age and sex | Complain | Tumor makers | Maximum diameter (mm) | CT (margin, attenuation, calcification, MTC) | FNAB | Invasion or metastasis | Management | Staging | Immunohistochemistry (positive) | Prognosis |
|---|---|---|---|---|---|---|---|---|---|---|---|
Fukunaga A [26] | 68-M | Discovered incidentally | Normal | 38 | Well-defined, heterogeneous, no, no | No | No | TR + TM, MS | II | CD5, Bcl-2, CD117, p63 | Survived>24 m, no recurrence |
Miura S [27] | 53-M | Discovered incidentally | NA | 70 | Ill-defined, heterogeneous, yes, no | Yes | Sternum and pleural | Chemotherapy | IVa | CK5, CD117, CD5, Bcl-2 | Survived>10Â m, no progression |
Kawashima O [15] | 58-M | Discovered incidentally | Normal | 60 | NA, heterogeneous, no, yes | Yes (insufficient) | No | TR + radiotherapy, MS | II | CK-pan, Ber-EP4 | Survived>25 m, no recurrence |
Posligua L [6] | 65-M | Discovered incidentally | NA | 80 | Well-defined, heterogeneous, no, no | Yes | No | TR + TM + LND + radiotherapy, MS | II | CK-pan, CD5, CD44, NSE | Survived>16 m, no recurrence |
Posligua L [6] | 50-M | Shortness of breath | NA | 135 | NA | Yes | No | TR + TM, MS | II | CK-pan, CD5, NSE | Survived>11 y, no recurrence |
Posligua L [6] | 73-M | NA | NA | NA | NA | No | Pericardium | TR + TM + radiotherapy, MS | III | CK-pan, CD5, NSE | Survived>33 m, no recurrence |
Phen S [28] | 57-M | Neck pain | CEA | 85 | Ill-defined, heterogeneous, yes, no | Yes | Liver | Chemotherapy | IVb | CD5, CD117, PAX8, p63 | Died |
Tagawa T [19] | 61-F | Discovered incidentally | NA | NA | Ill-defined, heterogeneous, no, no | Yes | Lung | Neoadjuvant chemoradiotherapy + TR + TM | IVb | CD5 | Survived>11 m, no recurrence |
Lee ACH [7] | 63-M | Chest pain | NA | 71 | Well-defined, heterogeneous, no, no | Yes | Lung | TR + CR + radiotherapy, MS | III | CK-pan, p63, p40 | Survived>10 m, no recurrence |
Suemitsu R [4] | 72-M | Discovered incidentally | Normal | NA | Ill-defined, heterogeneous, no, yes | No | Lung, vessels and pericardium | TR + CR + radiotherapy, MS | III | CD5 | NA |
Matsuo T [16] | 41-F | Chest pain | Normal | 50 | Well-defined, heterogeneous, no, no | Yes (insufficient) | Liver | TR + CR, MS | IVb | NA | Survived>24 m, recurrence |
Sakakura N [29] | 72-M | Discovered incidentally | NA | 65 | Well-defined, heterogeneous, no, no | No | No | TR + TM + CR, MS | II | CD5, CD117, Bcl-2 | Survived>36 m, recurrence |
Manthri S [2] | 61-F | Discovered incidentally | NA | 65 | NA | Yes | Liver | Chemotherapy | IVb | CK-pan, CD5, CD117, GATA3 | NA |
Siddiqui S | 58-F | Chest pain | NA | 72 | Well-defined, heterogeneous, no, no | Yes | Lung, pericardium | TR + CR + LND +chemoradiotherapy, MS | IVb | NA | Survived>6 m, no recurrence |
Buero A | 46-F | Chest pain | Normal | 50 | Ill-defined, heterogeneous, no, no | No | Sternum, trachea and vessels | Chemoradiotherapy | III | CK-pan, p63 | Survived>24Â m, no progression |