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Table 1 Baseline characteristics

From: Short- and Long-term survival prediction in patients with acute type A aortic dissection undergoing open surgery

Variables

Overall(n = 384)

Survivor (n = 342)

Non-survivor (n = 42)

P value

Gender (male, %)

307 (79.9)

273 (79.8)

34 (81.0)

0.930

Age (year)

56.09 (13.48)

55.82 (13.46)

58.26 (13.64)

0.268

BMI (kg/m2)

25.72 (3.45)

25.79 (3.46)

25.13 (3.28)

0.240

Hospitalization days (mean (SD))

16.71 (9.44)

17.79 (9.15)

7.98 (6.96)

 < 0.001

Time of onset (hour)

34.09 (86.45)

36.99 (91.17)

10.45 (6.30)

0.060

LUL SBP (mmHg)

132.43 (26.36)

132.98 (25.87)

128.00 (30.03)

0.249

LUL DBP (mmHg)

71.15 (17.65)

71.64 (17.30)

67.14 (20.13)

0.119

Heart rate (mean (SD))

81.61 (19.51)

81.61 (19.72)

81.62 (17.96)

0.997

Hypertension history (n, %)

287 (74.7)

256 (74.9)

31 (73.8)

0.891

Dialysis history (n, %)

8 (2.1)

5 (1.5)

3 (7.1)

0.004

Diabetes history (n, %)

15 (3.9)

14 (4.1)

1 (2.4)

0.906

Smoking (n, %)

141 (36.7)

121 (35.4)

20 (47.6)

0.167

Alcohol consumption (n, %)

95 (24.7)

83 (24.3)

12 (28.6)

0.674

Cerebral infarction history (n, %)

26 (6.8)

26 (7.6)

0 (0.0)

0.127

Coronary heart disease (n, %)

21 (5.5)

19 (5.6)

2 (4.8)

0.311

Lower Limb numbness (n, %)

66 (17.2)

57 (16.7)

9 (21.4)

0.579

Preoperative serological results

 WBC (10^9/L)

11.60 [8.80, 13.83]

11.45 [8.70, 13.78]

12.60 [10.95, 14.80]

0.045

 Neutrophil count (%)

9.90 [7.40, 12.20]

9.70 [7.23, 12.10]

10.55 [8.18, 12.95]

0.127

 Lymphocyte count (%)

0.90 [0.60, 1.20]

0.90 [0.60, 1.20]

0.95 [0.62, 1.10]

0.710

 Monocytes count (%)

0.60 [0.40, 0.90]

0.60 [0.40, 0.90]

0.75 [0.50, 0.90]

0.109

 Eosinophil count (%)

0.01 [0.00, 0.02]

0.01 [0.00, 0.02]

0.00 [0.00, 0.01]

0.282

 Basophil count (%)

0.01 [0.01, 0.03]

0.01 [0.01, 0.03]

0.02 [0.01, 0.03]

0.324

 PLT (10^9/L)

142.00 [113.00, 186.25]

141.50 [113.00, 185.75]

146.00 [117.25, 186.50]

0.950

 BNP (pg/ml)

58.50 [24.20, 154.00]

56.20 [24.20, 143.75]

71.20 [26.55, 189.00]

0.299

 ALT (U/L)

29.95 [22.00, 51.25]

29.00 [21.00, 48.75]

39.00 [27.25, 59.50]

0.013

 LDH (U/L)

392.50 [269.00, 534.75]

386.00 [263.25, 518.50]

472.00 [285.50, 663.50]

0.030

 Total bile acids (umol/L)

2.00 [1.00, 5.40]

1.80 [0.90, 4.70]

3.65 [1.42, 13.23]

0.002

 Adenosine deaminase (U/L)

10.80 [9.00, 14.20]

10.80 [8.90, 14.00]

11.50 [10.38, 19.35]

0.027

 Urea (mmol/L)

7.00 [5.70, 9.00]

6.90 [5.70, 9.00]

8.15 [5.40, 8.80]

0.704

 Creatinine (umol/L)

81.00 [63.77, 110.88]

78.05 [62.15, 105.25]

115.50 [77.18, 193.07]

 < 0.001

 Uric acid (umol/L))

384.50 [311.00, 463.25]

376.00 [309.50, 453.75]

466.50 [360.25, 545.00]

0.002

 TG (mmol/L)

1.11 [0.77, 1.75]

1.08 [0.79, 1.64]

1.25 [0.73, 2.18]

0.375

 Phosphorus (mmol/L))

1.12 [0.93, 1.34]

1.10 [0.91, 1.31]

1.23 [1.04, 1.55]

0.010

 CRP (mg/L)

8.10 [4.00, 33.60]

9.55 [4.10, 34.88]

7.00 [3.50, 18.05]

0.064

 eGFR (median [IQR])

87.75 [60.90, 114.73]

89.50 [62.00, 114.90]

69.75 [56.25, 101.30]

0.022

 cTn (ug/L)

0.02 [0.01, 0.09]

0.02 [0.01, 0.08]

0.06 [0.02, 0.18]

0.011

 PT (s)

12.40 [11.70, 13.60]

12.40 [11.60, 13.60]

12.50 [11.93, 13.60]

0.284

 INR (median [IQR])

1.09 [1.02, 1.19]

1.08 [1.02, 1.19]

1.14 [1.05, 1.21]

0.072

 APTT (s)

27.50 [25.90, 30.00]

27.45 [25.90, 29.90]

28.20 [26.30, 30.70]

0.259

 TT (s)

18.45 [16.90, 20.25]

18.30 [16.80, 20.17]

18.95 [17.72, 20.80]

0.068

 Fibrinogen (g/L)

2.20 [1.60, 3.00]

2.20 [1.60, 3.00]

2.05 [1.50, 2.40]

0.030

 D dimer (mg/L)

6.30 [3.22, 13.30]

5.81 [3.01, 12.15]

9.15 [6.15, 33.13]

 < 0.001

 SIRI

6.97 [4.19, 11.77]

6.94 [4.06, 11.73]

7.44 [5.52, 13.41]

0.189

 NLR

11.60 [7.00, 18.67]

11.60 [6.89, 18.67]

11.96 [8.35, 16.59]

0.605

 MLR

0.75 [0.50, 1.00]

0.75 [0.50, 1.00]

0.82 [0.56, 1.07]

0.390

 PLR

170.00 [122.50, 242.98]

170.56 [120.21, 243.65]

169.28 [136.05, 199.00]

0.807

 SII

1668.22 [1004.35, 2631.52]

1641.00 [989.40, 2628.30]

1878.36 [1117.73, 2709.18]

0.710

 Dimer(mg/L)

7.82 [3.18, 20.76]

7.28 [2.93, 19.46]

12.45 [6.35, 46.98]

0.004

 SCI

27.38 [16.80, 47.48]

27.85 [16.85, 50.97]

23.28 [16.24, 32.42]

0.102

Preoperative imaging results

  False lumen type ( n , %)

   

0.304

  Thromboembolic

177 (46.1)

157 (45.9)

20 (47.6)

 

  Patent Flow

151 (39.3)

138 (40.4)

13 (31.0)

 

  Partially Thromboembolic

56 (14.6)

47 (13.7)

9 (21.4)

 

 Multiple tears (n, %)

70 (18.2)

69 (20.2)

1 (2.4)

0.009

 Involvement of iliac arteries (n, %)

97 (25.3)

85 (24.9)

12 (28.6)

0.738

 MA in AD (n, %)

41 (10.7)

31 (9.1)

10 (23.8)

0.008

 RA in AD (n, %)

37 (9.6)

31 (9.1)

6 (14.3)

0.421

 FLM SS (n, %)

42 (10.9)

36 (10.5)

6 (14.3)

0.635

 FLM CS (n, %)

307 (79.9)

275 (80.4)

32 (76.2)

0.660

 Pericardial effusion (n, %)

313 (81.5)

276 (80.7)

37 (88.1)

0.340

 Pleural effusion (n, %)

52 (13.5)

49 (14.3)

3 (7.1)

0.296

 Associated aneurysms (n, %)

89 (23.2)

78 (22.8)

11 (26.2)

0.767

 True cavity (cm)

2.00 [2.00, 3.00]

2.20 [2.00, 3.00]

2.00 [2.00, 3.00]

0.431

 Ascending aortic diameter (cm)

5.00 [4.00, 5.50]

5.00 [4.00, 5.50]

5.00 [5.00, 5.50]

0.051

 True cavity total diameter ratio

0.50 [0.36, 0.63]

0.50 [0.36, 0.64]

0.42 [0.36, 0.57]

0.309

 False cavity (cm)

2.50 [1.50, 3.00]

2.50 [1.50, 3.00]

2.80 [2.00, 3.50]

0.132

 True to false cavity ratio (median [IQR])

1.00 [0.59, 1.75]

1.00 [0.60, 1.75]

0.80 [0.58, 1.52]

0.383

Operation data

 Stent type ( n , %)

   

0.023

  No stent

65 (16.9)

52 (15.2)

13 (31.0)

 

  TAA + DTA Stent

170 (44.3)

152 (44.4)

18 (42.9)

 

  DTA Stent

146 (38.0)

136 (39.8)

10 (23.8)

 

 Valve replacement (n, %)

75 (19.5)

65 (19.0)

10 (23.8)

0.593

 Aortic arch replacement ((n, %)

204 (53.1)

184 (53.8)

20 (47.6)

0.553

 CABG (n, %)

18 (4.7)

13 (3.8)

5 (11.9)

0.050

 Surgical duration (min)

408.57 (102.86)

405.33 (102.04)

434.88 (106.90)

0.079

  Extracorporeal bypass mode ( n , %)

0.040

  FA + AxArt + SVC/IVC

196 (51.0)

180 (52.6)

16 (38.1)

 

  FA + SVC/IVC

120 (31.2)

99 (28.9)

21 (50.0)

 

  AxArt + SVC/IVC

62 (16.1)

58 (17.0)

4 (9.5)

 

  AscAo + SVC/IVC

6 (1.6)

5 (1.5)

1 (2.4)

 

 ECPB (min)

203.97 (61.20)

201.40 (57.08)

224.90 (85.99)

0.019

 AXC (min)

148.23 (46.44)

147.63 (46.23)

153.07 (48.40)

0.474

 DHCAT (min)

29.26 (12.37)

29.18 (12.47)

29.93 (11.67)

0.712

 Postoperative CRRT (n, %)

71 (18.5)

46 (13.5)

25 (59.5)

 < 0.001

 Total plasma transfusion (*10 ml)

100.00 [75.00, 155.00]

100.00 [75.00, 144.38]

168.75 [108.12, 238.75]

 < 0.001

 Cryoprecipitated coagulation factors (IU)

9.75 [8.00, 13.75]

9.50 [8.00, 13.00]

12.12 [8.94, 15.00]

0.007

 Red Blood Cells Suspension (U)

9.00 [6.00, 13.50]

8.50 [6.00, 12.50]

15.50 [9.62, 26.12]

 < 0.001

 IMV (hour)

31.00 [16.75, 76.25]

25.00 [16.00, 66.00]

103.50 [56.00, 192.75]

 < 0.001

 ICU (hour)

121.00 [80.50, 182.50]

114.25 [80.50, 179.38]

140.75 [86.12, 228.38]

0.160

  1. Abbreviations : BMI Body mass index, LUL SBP Left upper extremity systolic blood pressure, LUL DBP Left upper extremity diastolic pressure, WBC White blood cell count, PLT Platelet count, BNP Brain Natriuretic Peptide, ALT Glutamate aminotransferase, LDH Lactate dehydrogenase, TG Triglycerides, cTn Troponin, PT Prothrombin time, INR International standardized ratio, APTT Activates partial prothrombin time, TT Thrombin time, SIRI Systemic inflammation response index, NLR Neutrophil-to-lymphocyte ratio, MLR Monocyte-to-lymphocyte ratio, PLR Platelet-to-lymphocyte ratio, SII, Systemic immune-inflammation index, SCI Systemic coagulation-inflammation index, Dimer/L,D Dimer-to- lymphocyte ratio, MA in AD Involvement of mesenteric arteries, RA in AD Involvement of renal arteries, FLM SS False lumen morphology (spiderweb sign), FLM CS False lumen morphology(crescent sign), TAA + DTA Stent Full arch and descending aortic stent implantation, DTA Stent descending aortic stent, CABG Coronary artery bypass graft surgery, FA Femoral artery, SVC Superior vena cava, IVC inferior vena cava, AxArt Axillary artery, AscAo Ascending aorta, ECPB Extracorporeal bypass time, AXC Aortic cross clamp time, DHCAT Deep hypothermic circulatory arrest time, IMV Postoperative invasive ventilator time, ICU Duration of stay in the monitoring unit