Table 3 Comparison of simultaneous and metachronous multiple primary lung cancers
Patient characteristics | Simultaneous multiple primary lung cancers (n = 171) | Metachronous multiple primary lung cancers (n = 31) | P value** | |
|---|---|---|---|---|
Age | 0.064 | |||
< 60 | 74 (43.3%) | 19 (61.3%) | ||
≥ 60 | 97 (56.7%) | 12 (38.7%) | ||
BMI | 0.013 | |||
≤ 24.9 | 107 (62.6%) | 12 (38.7%) | ||
> 24.9 | 64 (37.4%) | 19 (61.3%) | ||
Sex | 0.013 | |||
Male | 69 (40.4%) | 20 (64.5%) | ||
Female | 102 (59.6%) | 11 (35.5%) | ||
Smoking history | 0.027 | |||
Yes | 58 (33.9%) | 17 (54.8%) | ||
No | 113 (66.1%) | 14 (45.2%) | ||
Drinking history | 0.037 | |||
Yes | 28 (16.4%) | 10 (32.3%) | ||
No | 143 (83.6%) | 21 (67.7%) | ||
Personal history of neoplasia | 0.048 | |||
Yes | 20 (11.7%) | 0 (0.0%) | ||
No | 151 (88.3%) | 31 (100.0%) | ||
Family history of neoplasia | 0.847 | |||
Yes | 47 (27.5%) | 8 (25.8%) | ||
No | 124 (72.5%) | 23 (74.2%) | ||
Family history of lung cancer | 0.574 | |||
Yes | 29 (17.0%) | 4 (12.9%) | ||
No | 142 (83.0%) | 27 (87.1%) | ||
Past medical history | 0.966 | |||
Yes | 60 (35.1%) | 11 (35.5%) | ||
No | 111 (64.9%) | 20 (64.5%) | ||
Presented symptoms before the first surgery | 0.211 | |||
Yes | 70 (40.9%) | 9 (29.0%) | ||
No | 101 (59.1%) | 22 (71.0%) | ||
Number of resected tumors, n (%) | 0.751 | |||
2 | 134 (78.4%) | 26 (83.9%) | ||
3 | 27 (15.8%) | 5 (16.1%) | ||
4 | 7 (4.1%) | 0 (0.0%) | ||
5 | 2 (1.2%) | 0 (0.0%) | ||
6 | 1 (0.6%) | 0 (0.0%) | ||
Types of multiple cancers (GG/L nodules or second primary lung cancer) | 0.000 | |||
Multifocal GG/L nodules | 126 (73.7%) | 13 (41.9%) | ||
Second primary lung cancer | 45 (26.3%) | 18 (58.1%) | ||
Type(s) of surgery (thoracotomy/ VATS) | 0.000 | |||
VATS | 86 (50.3%) | 2 (6.5%) | ||
Thoracotomy | 69 (40.4%) | 15 (48.4%) | ||
Thoracotomy and VATS | 16 (9.4%) | 14 (45.2%) | ||
Type(s) of resection of multiple lesions | 0.046 | |||
Lobectomy + sublobar resection | 84 (49.1%) | 20 (64.5%) | ||
Lobectomy + lobectomy | 31 (18.1%) | 7 (22.6%) | ||
Sublobar resection + sublobar resection | 34 (19.9%) | 1 (3.2%) | ||
Lobectomy | 19 (11.1%) | 1 (3.2%) | ||
Pneumonectomy | 3 (1.8%) | 2 (6.5%) | ||
Relationship of the locations of multiple lesions | 0.037 | |||
Ipsilateral tumors | 111 (64.9%) | 14 (45.2%) | ||
Bilateral tumors | 60 (35.1%) | 17 (54.8%) | ||
With lung nodules not resected* | 0.147 | |||
Yes | 37 (21.6%) | 3 (9.7%) | ||
No | 134 (78.4%) | 28 (90.3%) | ||
The highest stage tumor | 0.499 | |||
I | 127 (74.3%) | 24 (77.4%) | ||
II | 15 (8.8%) | 4 (12.9%) | ||
III | 29 (17.0%) | 3 (9.7%) | ||